CHARLA DR. JOHN A. CIDLOWSKI

Nuestro colaborador internacional, Dr. John A. Cidlowski (National Institute of Environmental Health Sciences), dará la charla titulada «When Nuclear Receptors Meet in Cells and Animals«.

Save the date! 20 de enero de 2023, 11 AM (Chile) en el Aula Magna Irma Pennacchiotti Monti (Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile).

Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats

Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared the effect of repeated stress on the expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and N-methyl-D-aspartate (NMDA) receptor subunits in dorsal and ventral hippocampus (VH). Continuar leyendo «Chronic Stress Triggers Expression of Immediate Early Genes and Differentially Affects the Expression of AMPA and NMDA Subunits in Dorsal and Ventral Hippocampus of Rats»

II Concurso de Patentamiento y Transferencia Tecnológica

Estudiantes de la Facultad de Ciencias Químicas y Farmacéuticas de la Universidad de Chile obtuvieron tercer y cuarto lugar en el «II Concurso de Patentamiento y Transferencia Tecnológica».

Premiación que se llevó a cabo en el Instituto Nacional de Propiedad Intelectual (INAPI) el miércoles 16 de agosto de 2017.

Continuar leyendo «II Concurso de Patentamiento y Transferencia Tecnológica»

What Do We Really Know About 5-HT1A Receptor Signaling in Neuronal Cells?

Serotonin (5-HT) is a neurotransmitter that plays an important role in neuronal plasticity. Variations in the levels of 5-HT at the synaptic cleft, expression or dysfunction of 5-HT receptors may alter brain development and predispose to various mental diseases. Here, we review the transduction pathways described in various cell types transfected with recombinant 5-HT1A receptor (5-HT1AR), specially contrasting with those findings obtained in neuronal cells. The 5-HT1AR is detected in early stages of neural development and is located in the soma, dendrites and spines of hippocampal neurons. Continuar leyendo «What Do We Really Know About 5-HT1A Receptor Signaling in Neuronal Cells?»